Course syllabus

Course-PM

SSY091 Biomedical instrumentation Q1-2 HT20 (7.5 hp)

Course is offered by the department of Electrical Engineering

Contact details

Examiner and lecturer:

Sabine Reinfeldt, Associate Professor, Electrical Engineering. Direct phone 031-772 8063, Mobile 0708-141649, Email: sabine.reinfeldt@chalmers.se.

Lecturer:

Sofia Dall’Orso, Postdoc, Electrical Engineering. Email: dallorso@chalmers.se.  

Assistants:

Eva Lendaro, PhD student, Electrical Engineering. Email: lendaro@chalmers.se.

Jan Zbinden, PhD student, Electrical Engineering. Email zbinden@chalmers.se.

Tiffany Hamstreet, PhD student, Electrical Engineering. Email stager@chalmers.se.

Student representatives:

Lina Andreasson, liandrea@student.chalmers.se

Maximilian Eliasson, maxeli@student.chalmers.se

Shivani Ravichandran, shivani@student.chalmers.se

Health Resources

In this time of distant teaching, and especially now with the stricter regulations, I would like to remind/inform everyone that there is support to get in case of mental health issues, or just needing someone to talk to.

• You can always talk to your teacher or examiner, who can guide you further if needed. You are always welcome to contact me.
• Contact your student counselor. For MPBME, it is Lena Sommarström, and her email address is lenasom@chalmers.se. She can guide you further when needed. On this page, you can find contact persons for different programs.
• Also look at the useful information at the student portal on Medical Health. You can e.g. find contact details to the student care and what help you can get from them.

Another thing that is very important when sitting at home is to get physical exercise - now more than ever since you don't have to move between lectures or even home-Chalmers. In this link from WHO (Links to an external site.), you can find some advises and examples of different exercises. 

Course purpose

Aim: This course teaches basic knowledge in how to use traditional engineering disciplines, sensors, actuators and complex systems for clinical diagnosis and therapy, and the investigation of the physiological basis of diseases.

The learning outcomes of this course are partly applicable to other areas where sensors and actuators are combined for surveillance and control of a complex system for example the automotive sector.

Content: The course provides an overview of the biomedical engineering field from a system-oriented perspective, primarily in clinical diagnostics using examples from clinical physiology (for example ECG, EEG, EMG, respiratory function, blood pressure) and radiology. Principles and techniques used in electro-physiological measurement equipment is analyzed, designed, and verified. Most electronic equipment for biomedical use comprises sensors, amplifiers, and instruments for storage and presentation of the signal. Aspects of these units and their usage for various medical applications are discussed. A laboratory part of the course is the design and verification of electronics for electro-physiological registrations of the heart i.e. an ECG amplifier. Some state-of-the-art applications are discussed with invited experts in seminars. In most areas the latest findings and discoveries regarding clinical rehabilitation methods and devices are briefly presented.

 

Schedule

TimeEdit

Schedule for lectures and project presentations:

This is a preliminary schedule. Look for eventual daily changes at the course homepage. Yellow color coded lectures are mandatory.

Lectures on some topics (those given by Sabine and Sofia) will be provided online on Canvas a few days in advance, and QA-sessions are according to the schedule.

Quarter 1

	Date	Time	Loc	Section	Webster ed 4 / Tortora ed 10		Zoom link
	1 Sept	10-12	online	Introduction / Bone conduction hearing		SR	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/68129174210     Password: 498477
L1-2	7 Sept	13-15	online	QA: Amplifier circuits and Basic biochemistry	Chap. 3 (or 5e: 1.11-1.24) & 4 / 2,3	SR	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/65333281398     Password: 194930
	7 Sept	15-17	online	Electronics exercise	Amplifier_circuits_exercises_for_SSY091.pdf	EL	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/64044615010      Password: 132023
L3	8 Sept	10-12	online	QA: Electrodes 1	Chap. 4, 5 /9	SD	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/63113399462     Password: 409120
L4	10 Sept	10-12	online	Electrodes 2	Chap. 5	SM	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/68492875478     Password: 031260
L5	14 Sept	13-15	online	Cancelled
	14 Sept	15-17	online	Consultation Sessions: Home Assignment 1		TH	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/63946812138     Password: 049165
L6	17 Sept	10-12	online	QA: ECG 1 and ECG 2	Chap. 4, 6, 7	SR	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/63756277532     Password: 142246
L7	21 Sept	13-15	online	Project intro / QA: Blood pressure	Chap. 7	SR	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/67267785414     Password: 581685
L8	24 Sept	10-12	online	Respiratory system	Chap. 9	AS	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/66731504872     Password: 773203
L9	28 Sept	13-15	online	Prosthesis control/EMG		MO/SM	13.15-14.00: Max Ortiz-Catalan: Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/62364369826     Password: 130504   14.15-15.00: Silvia Muceli: Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/62666516254     Password: 467843
L10	1 Oct	10-12	online	Digital Health		BAS	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/69199548341
L11	5 Oct	13-15	online	QA: Blood flow	Chap. 8	SD	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/62995759255     Password: 759484
L12	8 Oct	10-12	online	EEG	Chap. 4	EL	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/63568865803      Password: 607575
	12 Oct	9-10	online	Monday Consultation: Home Assignment 2		TH	https://chalmers.zoom.us/j/61154111274     Password: 879576
	12 Oct	13-17	Online	Methodology workshop		EL	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/65365408619 Password: 874901
	13 Oct	9-10	online	Tuesday Consultation: Home Assignment 2		TH	https://chalmers.zoom.us/j/67849545242     Password: 972098
L13	15 Oct	10-12	online	Biosensors	Chap. 10	FH	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/63539480009     Password: 566118
	19 Oct	13-15	online	Reserve		SR
	22 Oct	10-12	online	QA: MR imaging	Chap. 12	SD	Topic: MR imaging Time: Oct 22, 2020 10:00 AM Amsterdam Sofia Dall'Orso is inviting you to a scheduled Zoom meeting. Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/65431519568     Password: 863602

 

Quarter 2 (Preliminary schedule - Look for eventual daily changes at the course homepage.)

	Date	Time	Loc	Section	Webster		Zoom link
L14	2 Nov	14-16	online	LabVIEW exercise Q&A		EL	zoom: https://chalmers.zoom.us/j/65656499978 waiting list: https://docs.google.com/document/d/1s_wHbMTkQ-kjc85JOJiGGHTbDtAQA46VrvqSXObI26Q/edit
	6 Nov (Friday)	8-12	online	Project planning meetings – 10 min per group		SR, JZ	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/61226637773
L15	9 Nov	13-15	online	QA: X ray / CT	Chap. 12	SD	Sofia Dall'Orso is inviting you to a scheduled Zoom meeting. Topic: X-ray/CT Time: Nov 9, 2020 01:00 PM Amsterdam Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/61599852953     Password: 981487
L16	12 Nov	10-12	online	Project workshop 1 – report writing		SR	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/66130461453     Password: 818056
	16 Nov	13-17	online	BCI seminar		g.tec	Register to the Webinar at this link: https://us02web.zoom.us/webinar/register/WN_pg4ggLx7Tkuq_t_DT9bpTw   Note: there will be a Kahoot at the end of the class!
	19 Nov	10-12	online	Ethics lecture		EL	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/67693010133     Password: 985499
	23 Nov	9-10	online	Consultation Session Home Assignment 3		TH	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/61371757572     Password: 605432
	23 Nov	13-17	online	Ethics workshop		EL	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/61210433569     Password: 936333 NOTE: use your Chalmers email to log in
L18	26 Nov	10-12	online	Certification of biomedical products		PJ	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/61483165898 Password: 891200
	30 Nov	13-15	online	Project workshop 2 – report supervision		CWC	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/67591293797     Password: 533616
L19	3 Dec	10-12	online	QA: Patient safety	Chap. 14	SR	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/65443387134     Password: 258586
	7 Dec	13-15	online	Reserve/Not needed
Pre A	10 Dec	9.15-12	online	Project presentation grp A		SR, JZ	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/63606563219     Password: 842743
Pre B	14 Dec	13.15-16	online	Project presentation grp B		SR, JZ	Join from PC, Mac, Linux, iOS or Android: https://chalmers.zoom.us/j/68395937667     Password: 889813

 

AL                       Alexander Lechner, g.tec medical engineering GmbH

AS                        Ants Silberberg, E2, Chalmers

BAS                     Bengt Arne Sjöqvist, E2, Chalmers

CWC                  Chalmers Writing Centre

EL                        Eva Lendaro, E2, Chalmers

FH                       Fredrik Höök, Biological Physics, Chalmers

JZ                        Jan Zbinden, E2, Chalmers

MO                     Max Ortiz Catalan, E2, Chalmers

PJ                         Per Johansson, Semcon

SD                        Sofia Dall'Orso, E2, Chalmers

SM                       Silvia Muceli, E2, Chalmers

SR                        Sabine Reinfeldt, E2, Chalmers

TH                       Tiffany Hamstreet, E2, Chalmers

Course literature

A.    Webster, Medical Instrumentation - Application and Design. John Wiley, NY, 4th ed. 2009 or 5th ed. 2020. Ed 5 soon available at Cremona for appr. 800 SEK. e-book at e.g. eu.wiley.com

Chapter references to Webster ed 4 (ed 5 will soon be added):

Chapter	Notes	Chapter	Notes
1	Whole as an overview	8	8.1 – 8.4, 8.6 – 8.8
2	2.1 – 2.6	9	9.1 – 9.6
3	Whole as an overview	10	10.1 – 10.3, 10.6
4	4.1 – 4.6, 4.8 – 4.9	11	Not included
5	Whole	12	Whole
6	6.1 ­– 6.6	13	Whole as an overview
7	7.1 – 7.8, 7.13	14	14.1-14.5, 14.7-14.9

Chapter references to Webster ed 5:

Chapter	Notes	Chapter	Notes
1	Whole as an overview	8	Whole
2	2.1 – 2.4, 2.5 – 2,7	9	9.1 – 9.6
3	Not included	10	10.1 – 10.3, 10.6
4	4.1 – 4.6, 4.8 – 4.9	11	Not included
5	Whole	12	Whole
6	6.1 ­– 6.6	13	Whole as an overview
7	7.1 – 7.8, 7.13	14	14.1-14.5, 14.7-14.9

 

B.     Tortora & Derrickson, Introduction to the Human Body, Wiley & sons, 10th ed. 2015 or 11th ed 2020. Chapters: 2, 3, 9. Available at Cremona for 599 SEK. e-book at e.g. eu.wiley.com

C.     Other literature for download will be made available through the course at the course homepage.

Course design

The course consists of lectures (including invited lectures), hand-in exercises, laboratory exercise, design workshop, ethics workshop and project work. For details, see below.

 

Lecture times (most often)                    Monday         13.15-15.00   Online, Zoom

                                                                                Thursday       10.00-11.45   Online, Zoom

 

Mandatory hand-in exercises

The three exercises listed below should be handed in no later than the time and date specified. All material should be made individually but you are allowed to discuss among colleagues. All text should be computer-written, but hand-written pictures and explaining schemes are allowed as appendices. Your solution should be in pdf-format and uploaded to the course homepage. Maximum one return is allowed. The assignments are generally corrected by Tiffany Hamstreet.

Hand-in        Subject                                                     Quarter                                 Deadline

Exercise 1:    ECG amplifier system                          q1                                        17 Sept, 5 pm

Exercise 2:    Neural Conduction                                q1                                        15 Oct, 5 pm

Exercise 3:    LabView exercise                                    q2                                        26 Nov, 5 pm                    

 

Mandatory laboratory exercise: The ECG amplifier

Work in pairs.

Simulation (Multisim) and building on bread boards at home – pick up ECG kit in the lab 29/9.

Measurements on campus in study week 7.

On campus location: Signaler och System lab, room 5225, 5th floor, E-House South wing.

Register on homepage (soon available)

Supervision by Jan Zbinden, Eva Lendaro and Tiffany Hamstreet

A laboratory report is mandatory and should be uploaded to the course home page in pdf-format by the latest 6 Nov, 5 pm.

 

Mandatory methodology workshop: Measurement of physiological parameters

Location: Zoom

Time: Monday 12 Oct, 13-17.

During this workshop you will be grouped and assigned a method for the measurement of a specific physiological parameter. Your task will be to gather information on the instrumentation required and illustrate its functioning and applications. The result will be presented in the form of a poster.

Supervision by Eva Lendaro.

 

Seminar on Brain Computer Interfaces: principles and applications in neurorehabilitation

Location: Zoom

Time: Monday 16 Nov, 13-17.

During this workshop you will learn about Brain Computer Interfaces (BCIs) and how they are realized. A specific focus will be given to application in neurorehabilitation and the use of a system for motor recovery of stroke patient will be demonstrated.

Given by Alexander Lechner from g.tec medical engineering GmbH.

 

Mandatory introduction to ethics in research:

Location: Zoom

Lecture: Thursday 19 Nov, 10-12

Workshop: Monday 23 Nov, 13-17.

You will learn about research ethics by reading material, lecture, and group work during a workshop.  

Given by Eva Lendaro.

 

Mandatory Project work

During the 2^nd quarter, about 40 hours for each person will be spent on deeper studies in elected projects. This work will be performed in groups of 3 students. To pass, the followings are required:

1. A computer-written report (exactly 10 pages) and an oral presentation (PowerPoint) should be approved. The report should be uploaded in pdf-format to the project folder at the course home page no later than Dec 3, 5 pm.
2. Participation in one of the presentation sessions that takes place during two different occasions:
   Dec 10, at 8.30-12 and Dec 14, at 13.15-16.30, on Zoom .
   PowerPoint presentations should be uploaded no later than 5 pm the day before the oral presentation at the course homepage.

Supervision by Sabine Reinfeldt and Jan Zbinden

 

Time budget

This is a 7.5 credit course, which corresponds to 200 hours. The following chart shows estimations for how much time you need to spend on the different course events for a passing grade (in total 200 hours).

 

 

• 3 hours per lecture - 1 hour study time for each lecture. 74 hours including 18 lectures, 9 QA-session, 1 exercise, and online quizzes.
• 10-15 hours per hand in exercise
• 40 hours project work
• 23 hours laboratory exercise including report writing
• 4 hours for project workshops plus 3 hours of preparation time
• 4 hours methodology workshop
• 4 hours BCI seminar
• 8 hours ethics including 2 h preparations, 2 h lecture, 4 h workshop

 

Changes made since the last occasion

• The prerecorded videos are new, except for the first two lectures.
• Several course events are now transformed to digital teaching.
• Smaller groups and adjustments made in the laboratory sessions on campus.
• Sofia Dall'Orso is new lecturer.
• Tiffany Hamstreet and Jan Zbinden are new as teaching assistants (Jan has had some of the laboratory supervision before). 
• New edition of the course books.

Learning objectives and syllabus

Learning objectives:

• describe physiological functions of the human body, from their molecular origin to how and why they are measured, as well as describe the molecular origin of disease states; 
• explain how sensors and measurement systems can be used to monitor physiological functions of the human body, how these data can be used to improve and support decisions by health care personnel, and in some applications analyze what is limiting the system performance;
• describe how a biomedical instrumentation system is used in selected applications;
• describe, simulate, construct and operate an ECG biopotential amplifier and analyze the result;
• estimate and describe safety aspects of biomedical instrumentation systems;
• in oral presentations and written report in English, describe and motivate biomedical systems to technical as well as non-technical specialists;
• seek and acquire information from relevant scientific publications when working in a project team; 
• discuss ethical aspects on research and development of selected biomedical instrumentation systems.

Link to the syllabus on Studieportalen: Study plan

Examination form

To be approved grade 3, no final written exam is required, but within deadlines:

• The online quizzes must be taken.
• All hand-in exercises must be approved.
• The laboratory exercise and the laboratory report must be approved.
• Active participation in the methodology workshop.
• Active participation in the ethics lecture and workshop.
• The project work including report and oral presentation must be approved.

 

The grading system below with points for all mandatory course elements together with a voluntary home exam will give your final grade.

 

Element	Condition	Grading 2020		Comments
		min	max
Hand-in assignments	Mandatory	13	27	1: 5-9, 2: 4-9, 3: 4-9
Online quizzes	Mandatory	1	1
Lab incl report	Mandatory	7	9
Methodology workshop	Mandatory	4	5
Ethics	Mandatory	2	2
Project work	Mandatory	13	26
	Subtotal:	40	70
Home exam	Voluntary	0	30
	Total:	40	100
	Grading:
	3		40
	4		60
	5		80