Course syllabus

Course-PM

KBT315 KBT315 Advanced analytical chemistry lp2 HT23 (7.5 hp)

Course is offered by the department of Chemistry and Chemical Engineering

Contact details

Examiner: Ann-Sofie Cans - E-mail cans@chalmers.se

Teachers:

Jan-Olof Svensson (JOS), Astra Zeneca.              JanOlof.Svensson@astrazeneca.com

Per Malmberg (PM), Chalmers                              malmper@chalmers.se

 Ann-Sofie Cans (ASC), Chalmers                         cans@chalmers.se

 Magnus Fransson (MF) Astra Zeneca                  Magnus.Fransson@astrazeneca.com

 

Laboratory supervisors:

Arkesia Santana Damascena                    arkecia@chalmers.se

Rui Liu                                                         rui.liu@chalmers.se

Daniel Hoffmann                                       danhof@chalmers.se

 

Course purpose

This advanced analytical chemistry course is intended to provide a deepened understanding of the practical aspects of chemical analysis, including design of sampling protocols, sample pre-treatment, data handling and of the instrumentation used in modern chemical analysis. The students will practice thinking critically and make informed choices between proposed analytical instrumentations and methods.
The course will teach the principles of quality control and assurance and enable students to apply their knowledge to the practical solution of real analytical problems. The course will provide familiarity with current analytical literature to enable you to review, select, read, and critically discuss the papers most relevant to a particular topic. Students will further develop the techniques of communication, including report
writing and oral presentation, and will receive training in independent literature study..

Schedule

TimeEdit

Course literature

Course Textbook: The course is based on the fundamental principles covered in Quantitative Chemical Analysis by Daniel Harris, 6th. Ed. or later but does not follow the book structure. Individual textbook study is highly recommended to be able to pass the in-class test and participate efficiently in the seminars.

Recommended alternative: Analytical Chemistry 2.1 - D. Harvey

This e-book is free of charge to download. However, this book offers no section on the topic mass spectrometry. The book can be downloaded here:

http://dpuadweb.depauw.edu/harvey_web/eTextProject/version_2.1.html

 

 Reading Chapters in the course textbook by Harris and the eBook by Harvey:

Topic	Chapter D.C. Harris	Chapter D. Harvey
The analytical process & sample preparation	28	7, 18
Chemical separations	23	12
Chromatography Theory	26	12B
Gas Chromatography	24	12D
Liquid Chromatography	25	12E
Spectroscopy methods	19,20,21	10B, 10C, 10 D, 10 G
Mass spectrometry	22
Electroanalytical Chemistry	14,15,17	11
Uncertainties in analytical measurements	3	4
Figure of merits, calibrations, validation	5	3

 

The chapters in the different editions of Harris vary, but the content of each chapter is fully sufficient no matter the edition. Material related to mass spectrometry and biosensors will be handed out in connection to the mass spectrometry lectures.

 

Course design

Lectures: The course is structured with lectures at Tuesdays 13.15-15.00 and 15.15 - 17.00, with one exception to also one Thursday afternoon on the 7th of November.  

Laboratory work: Two problem-solving labs are included in the course, where student will use the available equipments LC-MS, GC-MS and UV/VIS.  Laboratory experiments are scheduled for 10 half day exercises where the pre-assigned groups meet at the designated dates according to the lab schedule and lab groups in Kurshuset Lab 5117. Admission into the lab requires wearing a lab coat and proper shoes. Safety glasses are provided.

Students are handed material to read and process before showing up to the labs. This will also improve the speed of your experimental success. This course offers training in the analytical process, with focus to training in designing your own lab manuals, process data and present the experimental results. Guidelines are provided to the following two lab assignments:

• Determination of the concentration of gold nanoparticles in a sample solution
• Determination of the amount paracetamol in pharmaceutical products

Literature assignments presentations

 On Tuesday 17^th of December 13.15-17.00 and Thursday 19^th of December 13.15-17.00 students will present the individual literature projects.  

 The course includes a mandatory individual literature project where students will write individual project report and present the project at a workshop at the end of this course.

In-class quiz: Two 10-minutes quiz during the course will test knowledge gained from lectures.

Guidelines for in-class test:

The tests contain basic questions and calculations. This in-class test is evaluated to measure your ongoing performance during the course. The evaluation does not influence the final course grade. You have to reach at least 50% of the score in each test to pass the course. If you score less than 50% in the in-class test, you will have to prepare a home assignment on the failed subjects. Failure to produce this essay within two weeks will result in failure of the course.

Questions about the course can be e-mailed to the teachers and supervisors, where general questions can be directed to the examiner.

 

Changes made since the last occasion

A summary of changes made since the last occasion.

Learning objectives and syllabus

Learning objectives:

• explain the analytical process
• select appropriate analytical techniques and methods for a given problem including sample pre-treatment, instrumental techniques, method validation and data processing
• understand the use of multivariate statistics to a variety of data with emphasis on spectroscopic data
• explain and compare analytical techniques
• use GC-MS, LC-MS, UV/VIS
• design and modify analytical protocols
• interpret mass spectra obtained by GC-MS or LC-MS
• apply good laboratory practice
• evaluate and critically examine data and literature
• present results in relation to state of the art, both written and orally.
• understand the ethical problems and principles in science and engineering with specific focus on the analytical sciences

 

Link to the syllabus on Studieportalen.

Study plan

Examination form

1. Literature assignment:: Paper confirmation: 12^th of November. One individual report to be handed in until Tuesday 10^th of December

2. Course workshop: Exam equivalent: presence is mandatory for everyone in the session where you present. Written guidelines are provided.

3. Two different laboratory experiments and submission of a lab report for each of the two experiments. One report per group is sufficient, but individual reports are also accepted. Written guidelines are provided.

4. Two in-class test:  10 min time will be dedicated to each test. The test is to assess your study progress based on the lecture material the week before. The in-class test is composed of 6 questions regarding basic subjects complementing the lectures up to the date of the test. Written guidelines are provided.