Course-PM

SSY091 Biomedical instrumentation Q1-2 HT19 (7.5 hp)

Course is offered by the department of Electrical Engineering

Contact details

Examiner and lecturer:

Sabine Reinfeldt, Associate Professor, Electrical Engineering, room 7416, E building. Direct phone 031-772 8063, Mobile 0708-141649, Email: sabine.reinfeldt@chalmers.se.

Assistants:

Eva Lendaro, PhD student, Electrical Engineering, room 7310, E building. Direct phone 031-772 3714, Mobile 0704-231352, Email: lendaro@chalmers.se.

Autumn Naber, PhD student, Electrical Engineering, room 7314, E building. Mobile 073-856 7762, Email naber@chalmers.se.

Course purpose

Aim: This course teaches basic knowledge in how to use traditional engineering disciplines, sensors, actuators and complex systems for clinical diagnosis and therapy, and the investigation of the physiological basis of diseases.

The learning outcomes of this course are partly applicable to other areas where sensors and actuators are combined for surveillance and control of a complex system for example the automotive sector.

Content: The course provides an overview of the biomedical engineering field from a system-oriented perspective, primarily in clinical diagnostics using examples from clinical physiology (for example ECG, EEG, EMG, respiratory function, blood pressure) and radiology. Principles and techniques used in electro-physiological measurement equipment is analyzed, designed, and verified. Most electronic equipment for biomedical use comprises sensors, amplifiers, and instruments for storage and presentation of the signal. Aspects of these units and their usage for various medical applications are discussed. A laboratory part of the course is the design and verification of electronics for electro-physiological registrations of the heart i.e. an ECG amplifier. Some state-of-the-art applications are discussed with invited experts in seminars. In most areas the latest findings and discoveries regarding clinical rehabilitation methods and devices are briefly presented.

 

Schedule

TimeEdit

Schedule for lectures and project presentations:

This is a preliminary schedule. Look for eventual daily changes at the course homepage. Color coded lectures are mandatory: blue counts as invited lectures, while yellow belongs to another mandatory course event.

Quarter 1

	Date	Time	Loc	Section	Webster / Tortora
	3 Sept	10-12	HC2	Introduction / Bone conduction hearing		SR
L1&2			Online	Amplifier circuits & Biochemistry	Chap. 3,4 /2,3	SR
	9 Sept	13-15	EC	QA-session for L1&2		SR
	9 Sept	15-17	EC	Electronics exercise		EL
L3	10 Sept	10-12	HC1	Electrodes 1	Chap. 4, 5 /9	SR
L4	12 Sept	10-12	EC	Electrodes 2	Chap. 5	SR
L5	16 Sept	13-15	EC	ECG 1	Chap. 4, 6	SR
L6	19 Sept	10-12	EC	Cancelled!		SR
L7	23 Sept	13-15	EC	ECG 2	Chap. 4, 6, 7	SR
L8	26 Sept	10-12	EC	Respiratory system	Chap. 9	AS
L9	30 Sept	13-15	EC	eHealth/ EMG		BAS/LS
L10	3 Oct	10-12	EC	Blood pressure / Project intro	Chap. 7	SR
L11	7 Oct	13-15	EC	Biosensors	Chap. 10	FH
L12	10 Oct	10-12	EC	EEG	Chap. 4	EL
	14 Oct	13-17	EL42-43, ES51	Methodology workshop		EL
L13	17 Oct	10-12	EC	Blood flow	Chap. 8	SR
	21 Oct	13-17	EC	BCI workshop		AL
	24 Oct	10-12	EC	Prosthesis control		MO

 

Quarter 2 (Preliminary schedule - Look for eventual daily changes at the course homepage.)

	Date	Time	Loc	Section	Webster
	4 Nov	13-15		Cancelled!
	7 Nov	9.20-12	Landahls-rummet	Project planning meetings – 10 min per group		SR, EL
L14	11 Nov	13-16.30	SB-D309	LabVIEW exercise		EL
L15	14 Nov	10-12	EC	MR imaging	Chap. 12	OJ
	18 Nov	13-15	EC	Cancelled!
	18 Nov	15-17	EA	Project workshop 1 – report writing		SR
L16	26/11 & 3/12	26/11: 16.25-19.30 3/12: 16.25-18.00	Sahlgrenska Blå Stråket 5	Study tour X-Ray lab Sahlgrenska, 26/11: Group 1-3 16.25-18.00, 4-6 17.55-19.30, and 3/12: Group 7-9 16.25-18.00		Rad SU
	21 Nov	10-12	EC	Ethics lecture		EL
	25 Nov	13-17	EC	Ethics workshop		EL
L17	28 Nov	10-12	EC	Certification of biomedical products		PJ
	2 Dec	15-17	EL41-43, ES52-53	Project workshop 2 – report supervision		CWC
L18	5 Dec	10-12	EC	Patient safety	Chap. 14	SR
L19	9 Dec	13-15	EC	X ray / CT	Chap. 12	JE
	12 Dec	10-12	EC	Reserve
Pre A	16 Dec	8.30-12	EC	Project presentation grp A		SR
Pre B	16 Dec	13-16.30	EC	Project presentation grp B		SR

 

AL                       Alexander Lechner, g.tec medical engineering GmbH

AS                        Ants Silberberg, E2, Chalmers

BAS                     Bengt Arne Sjöqvist, E2, Chalmers

CWC                   Chalmers Writing Centre

EL                        Eva Lendaro, E2, Chalmers

FH                       Fredrik Höök, Biological Physics, Chalmers

JE                        Jörgen Elgqvist, Radiology, Sahlgrenska

LS                        Leif Sandsjö, University of Borås

MH                      Maria Hultenmo, Radiology, Sahlgrenska

MO                      Max Ortiz Catalan, E2, Chalmers

OJ                        Oscar Jalnefjord, Radiology, Sahlgrenska

PJ                         Per Johansson, Semcon

Rad SU               Radiology, Sahlgrenska

SR                        Sabine Reinfeldt, E2, Chalmers

Course literature

A.    Webster, Medical Instrumentation - Application and Design. John Wiley, NY, 4th ed. 2009. Available at Cremona. e-book at e.g. eu.wiley.com

Chapter references to Webster:

Chapter	Notes	Chapter	Notes
1	Whole as an overview	8	8.1 – 8.4, 8.6 – 8.8
2	2.1 – 2.6	9	9.1 – 9.6
3	Whole as an overview (espec. M & K)	10	10.1 – 10.3, 10.6
4	4.1 – 4.6, 4.8 – 4.9	11	Not included
5	Whole	12	Whole
6	6.1 ­– 6.6	13	Whole as an overview
7	7.1 – 7.8, 7.13	14	14.1-14.5, 14.7-14.9

 

B.     Tortora & Derrickson, Introduction to the Human Body, Wiley & sons, 10th ed. 2015. Chapters: 2, 3, 9. Available at Cremona for 589 SEK. e-book at e.g. eu.wiley.com

C.     Other literature for download will be made available through the course at the course homepage.

Course design

The course consists of lectures (including invited lectures), hand-in exercises, laboratory exercise, design workshop, ethics workshop and project work. For details, see below.

 

Lecture times (most often)                    Monday         13.15-15.00   Room EC

                                                                                Thursday       10.00-11.45   Room EC

 

Mandatory hand-in exercises

The three exercises listed below should be handed in no later than the time and date specified. All material should be made individually but you are allowed to discuss among colleagues. All text should be computer-written, but hand-written pictures and explaining schemes are allowed as appendices. Your solution should be in pdf-format and uploaded to the course homepage. Maximum one return is allowed. The assignments are generally corrected by Autumn Naber.

Hand-in        Subject                                                     Quarter                                 Deadline

Exercise 1:    ECG amplifier system                          q1                                        19 Sept, 5 pm

Exercise 2:    Neural Conduction                                q1                                        17 Oct, 5 pm

Exercise 3:    LabView exercise                                    q2                                        28 Nov, 5 pm                    

 

Mandatory laboratory exercise: The ECG amplifier

Location: Lab Signaler och System, 5225, 5th floor, E-House South wing.

Tuesday/Wednesday group:  24 Sept (8-12), 15 Oct (8-12), 22 Oct (8-12), 6 Nov (13-17), 13 Nov (13-17)

Friday group:                                   27 Sept (8-12), 18 Oct (8-12), 25 Oct (8-12), 8 Nov (13-17), 15 Nov (13-17)

This lab is normally finalized after four or five sessions. It is mainly supervised by Eva Lendaro and Autumn Naber.

A laboratory report is mandatory and should be uploaded to the course home page in pdf-format by the latest 28 Nov, 5 pm.

 

Mandatory methodology workshop: Measurement of physiological parameters

Location: EL41 – EL43

Time: Monday 14 Oct, 13-17.

During this workshop you will be grouped and assigned a method for the measurement of a specific physiological parameter. Your task will be to gather information on the instrumentation required and illustrate its functioning and applications. The result will be presented in the form of a poster.

Supervision by Eva Lendaro.

 

Workshop on Brain Computer Interfaces: principles and applications in neurorehabilitation

Location: EC

Time: Monday 21 Oct, 13-17.

During this workshop you will learn about Brain Computer Interfaces (BCIs) and how they are realized. A specific focus will be given to application in neurorehabilitation and the use of a system for motor recovery of stroke patient will be demonstrated.

Given by Alexander Lechner from g.tec medical engineering GmbH. Registration needed.

 

Mandatory introduction to ethics in research:

Location: EC

Lecture: Thursday 21 Nov, 10-12

Workshop: Monday 25 Nov, 13-17.

You will learn about research ethics by reading material, lecture, and group work during a workshop.  

Given by Eva Lendaro.

 

Mandatory Project work

During the 2^nd quarter, about 45 hours for each person will be spent on deeper studies in elected projects. This work will be performed in groups of 2-3 students. To pass, the followings are required:

1. A computer-written report (exactly 10 pages) and an oral presentation (PowerPoint) should be approved. The report should be uploaded in pdf-format to the project folder at the course home page no later than Dec 5, 5 pm.
2. Participation in one of the presentation sessions that takes place during two different occasions:
   Dec 16, at 8.30-12 in EC and Dec 16, at 13.15-16.30 in EC.
   PowerPoint presentations should be uploaded no later than 5 pm the day before the oral presentation at the course homepage.

Supervision by Sabine Reinfeldt and Eva Lendaro

 

Time budget

This is a 7.5 credit course, which corresponds to 200 hours. The following chart shows estimations for how much time you need to spend on the different course events for a passing grade (in total 200 hours).

 

 

• 3 hours per lecture - 1 hour study time for each lecture. 66 hours including 19 lectures, 1 QA-session, 1 exercise, and online quiz.
• 10-15 hours per hand in exercise
• 45 hours project work
• 23 hours laboratory exercise including report writing
• 5 hour study tour with 1.5 hour preparation and reflection time
• 4 hours for project workshops plus 3 hours of preparation time
• 4 hours methodology workshop
• 4 hours BCI workshop
• 8 hours ethics including 2 h preparations, 2 h lecture, 4 h workshop

 

Changes made since the last occasion

• Autumn Naber is new as teaching assistant and Eva Lendaro is giving the EEG lecture and the ethics introduction for the first time
• The BCI workshop is new
• Attempt to handle the home assignment corrections only via the course home page

Learning objectives and syllabus

Learning objectives:

• describe physiological functions of the human body, from their molecular origin to how and why they are measured, as well as describe the molecular origin of disease states; 
• explain how sensors and measurement systems can be used to monitor physiological functions of the human body, how these data can be used to improve and support decisions by health care personnel, and in some applications analyze what is limiting the system performance;
• describe how a biomedical instrumentation system is used in selected applications;
• describe, simulate, construct and operate an ECG biopotential amplifier and analyze the result;
• estimate and describe safety aspects of biomedical instrumentation systems;
• in oral presentations and written report in English, describe and motivate biomedical systems to technical as well as non-technical specialists;
• seek and acquire information from relevant scientific publications when working in a project team; 
• discuss ethical aspects on research and development of selected biomedical instrumentation systems.

Link to the syllabus on Studieportalen: Study plan

Examination form

To be approved grade 3, no final written exam is required, but within deadlines:

• The online quizzes on L1 and L2 must be taken.
• All hand-in exercises must be approved.
• The laboratory exercise and the laboratory report must be approved.
• Active participation in the methodology workshop.
• Active participation in the ethics lecture and workshop.
• The project work including report and oral presentation must be approved.
• Participation in at least 80% of the invited lectures, including the study tour. If the participation is less, the home exam is mandatory to pass the course.

 

The grading system below with points for all mandatory course elements together with a voluntary home exam will give your final grade.

 

Element	Condition	Grading 2019		Comments
		min	max
Invited lectures	Mandatory 7/10	1	3	incl study tour.
Hand-in assignments	Mandatory	13	25	1: 5-8, 2: 4-9, 3: 4-8
Online quiz	Mandatory	1	1
Lab incl report	Mandatory	6	8
Methodology workshop	Mandatory	4	5
BCI workshop	Voluntary	0	1
Ethics	Mandatory	2	2
Project work	Mandatory	13	25
	Subtotal:	40	70
Home exam	Voluntary	0	30
	Total:	40	100
	Grading:
	3		40
	4		60
	5		80